Validation of Bucca/Saliva Samples and Finger Prick Blood Sample Collected with COPAN FLOQSwab to Detect Human Cytomegalovirus IGG Antibodies

Infection with cytomegalovirus (CMV) is very common with seropositivity rates ranging from 40% in developed countries up to 100% in developing countries. CMV transmission may occur by salivary contact or by blood transfusion, therefore all stem cells, bone marrow, solid organs and blood donors and prenatal patients must be screened in order to determine the CMV immunity. The enzyme-linked immunosorbent assay (ELISA) is the most commonly used serologic test for measuring antibody to CMV. A positive test for CMV IgG indicates that a person was infected with CMV at some time during their life. A blood sample is usually used for CMV immunity testing therefore participants to donors or prenatal screening programs are discouraged to participate due to the blood collection procedure. A noninvasive sample like saliva/buccal swab would be more acceptable for CMV antibody screening.