Scientific Study Library
Thank you for visiting COPAN's Scientific Studies Library, your online resource for proof sources related to COPAN products as well as many other aspects of sample collection and transport, automation, food and pharmaceutical testing, forensic and genetic collection and more!
Comparison of Results Obtained with the FilmArray GI Panel using rectal Swabs and Cary-Blair Stool from Patients with Gastroenteritis in the Pediatric Emergency Department
Automated Scoring of Chromogenic Media for the Detection of MRSA Using the WASPLab Image Analysis Software
Comparison of the Copan ESwab System with an Agar Swab Transport System for Maintenance of Fastidious Anaerobic Bacteria Viability
Relative sensitivity of anterior nares and nasopharyngeal swabs for initial detection of SARS-CoV-2 in ambulatory patients: Rapid review and meta-analysis
Abstract Nasopharyngeal (NP) swabs are considered the “gold standard” for diagnosing SARS-CoV-2 infections, but anterior nares or mid-turbinate swabs (nasal swabs) are often used. We performed a meta-analysis comparing the sensitivity of nasal and nasopharyngeal swabs against a composite reference standard for the initial diagnosis of SARS-CoV-2 infection inambulatory patients. The study is registered on…Read More
Multicenter Evaluation of Processing and Analysis of CAP Proficiency Testing Samples by Laboratory Automation
To maintain their Clinical Laboratory Improvement Amendment (CLIA) accreditation, clinical laboratories are expected to enroll in proficiency testing (PT) to confirm that all parts of the diagnostic testing process perform as expected (1). In recent years, an increasing number of clinical microbiology laboratories have adopted laboratory automation for processing and incubation of specimens submitted for…Read More
Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV-2 Molecular Detection: A Systematic Review and Meta-analysis
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. ABSTRACT Background Nasopharyngeal (NP) swabs are considered the highest-yield sample for diagnostic testing for respiratory viruses, including SARS-CoV-2. The need to increase capacity…Read More
Copan eNAT™ Transport System to Address Challenges in COVID-19 Diagnostics in Regions with Limited Testing Access
ABSTRACT Community-based healthcare clinics and hospital outreach services have the potential to expand coronavirus disease 2019 (COVID-19) diagnostics to rural areas. However, reduced specimen stability during extended transport, the absence of cold chain to centralized laboratories, and biosafety concerns surrounding specimen handling has limited this expansion. In the following study, we evaluated eNAT (Copan Italia,…Read More
Variability in instructions for performance of nasopharyngeal swabs across Canada in the era of COVID-19 – what type of swab is actually being performed?
Abstract Background The primary method of surveillance for the presence of SARS-CoV-2 is with nasopharyngeal swabs. Given the significant demand for nasopharyngeal swabs, a large number of previously untrained and unfamiliar staff are now performing this test. It was noted that there was significant heterogeneity in instructions for performing nasopharyngeal swabs in Canada, in contrast…Read More
The impact of viral transport media on PCR assay results for the detection of nucleic acid from SARS-CoV-2
Sir, For several decades a variety of medium solutions have been recommended to stabilise specimens for the detection of bacteria and viruses, particularly during diagnostic investigations. These have usually been based on balanced salt or saline solutions with a buffering capacity to maintain a ‘near-neutral’ pH. To enhance the stability of viruses a spectrum of…Read More
Abstract Widely available and easily accessible testing for COVID-19 is a cornerstone of pandemic containment strategies. Nasopharyngeal swabs (NPS) are the currently accepted standard for sample collection but are limited by their need for collection devices and sampling by trained healthcare professionals. The aim of this study was to compare the performance of saliva to…Read More
Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study
Abstract Background The PCV13 immunization demonstration program began in October 2017 in Indonesia. The aim of this study is to assess the dynamic changes of pneumococcal serotype before and after PCV13 administration, with two primary and one booster doses. Methods The prospective cohort study was conducted as a follow up study measuring the impact of…Read More
Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020
Abstract In February and March, 2020, environmental surface swab samples were collected from the handle of the main entry door of a major university building in Florida, as part of a pilot surveillance project screening for influenza. Samples were taken at the end of regular classroom hours, between the dates of February 1–5 and February…Read More
ABSTRACT Testing efforts for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been burdened by the scarcity of testing materials and personal protective equipment for health care workers. The simple and painless process of saliva collection allows for widespread testing, but enthusiasm is hampered by variable performance compared to that of nasopharyngeal swab (NPS) samples.…Read More
Abstract Purpose PCR on a nasopharyngeal sample is the reference method for the detection of SARS-nCoV-2. However, combined throat/nasal sampling as a testing method has several advantages. We compared the combined throat/nasal sampling with nasopharyngeal sampling for detection of SARS-CoV-2 in healthcare workers suspected of COVID-19. Methods In 107 healthcare workers with symptoms of COVID-19,…Read More
An in-well direct lysis method for rapid detection of SARS-CoV-2 by real time RT-PCR in eSwab specimens
Abstract Background Diagnostic real time reverse transcription PCR (rRT-PCR) is usually done using nucleic acid (NA) purified from the sample. In the SARS-CoV-2 pandemic reagents and utensils for NA purification has been in short supply. This has generated interest in methods that eliminate the need for NA purification. Objectives To investigate if addition of detergent…Read More
Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses — Wisconsin, September–October 2020
Summary What is already known about this topic? Antigen tests for SARS-CoV-2 are inexpensive and can return results within 15 minutes, but test performance data in asymptomatic and symptomatic persons are limited. What is added by this report? Compared with real-time reverse transcription–polymerase chain reaction (RT-PCR) testing, the Sofia antigen test had a sensitivity of…Read More
To the Editors: In December 2019 appeared in China a novel coronavirus, designated as SARS-CoV-2, responsible for a pandemic respiratory disease, known as coronavirus disease, with the Italian outbreak from February 2020. Children appear to have milder symptoms and less severe disease.1 The tests currently used for the direct identification of SARS-CoV-2include specimens taken from…Read More
Abstract: The first pediatric study demonstrating significantly higherpositivity rate of nasal (mid-turbinate) swab testing over oropharyngealswab testing in detecting SARS-CoV-2 (Fisher exact test 0.046, Cohen K0.43, confidence interval 95%, 0.014–0.855). Benefits might include lowercollection-related hazard for healthcare workers. We recommend it as preferred choice for swab-based SARS-CoV-2 testing in children.Read More
Some of the studies in this database are independent scientific studies performed by third parties, while some of the studies were partially or entirely funded by COPAN. In addition to peer reviewed research this library also contains posters, which were presented at various scientific meetings, and may not have been subject to peer review.
Some of the studies found here may contain information about off label product use. Studies, product claims and availability may vary from country to country, and they are subject to varying regulatory requirements. Always refer to product labeling, package inserts and safety data sheets for the appropriate use of the products.