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Scientific Study Library

Thank you for visiting COPAN's Scientific Studies Library, your online resource for proof sources related to COPAN products as well as many other aspects of sample collection and transport, automation, food and pharmaceutical testing, forensic and genetic collection and more!

Comparison of Results Obtained with the FilmArray GI Panel using rectal Swabs and Cary-Blair Stool from Patients with Gastroenteritis in the Pediatric Emergency Department

Automated Scoring of Chromogenic Media for the Detection of MRSA Using the WASPLab Image Analysis Software

Comparison of the Copan ESwab System with an Agar Swab Transport System for Maintenance of Fastidious Anaerobic Bacteria Viability

Automation in the Clinical Microbiology Laboratory

Latest Studies:

Evaluation of Commercially Available Viral Transport Medium (VTM) for SARS-CoV-2 Inactivation and Use in Point-of-Care (POC) Testing

November 11, 2021

Abstract: Critical to facilitating SARS-CoV-2 point-of-care (POC) testing is assurance that viruses present in specimens are inactivated onsite prior to processing. Here, we conducted experiments to determine the virucidal activity of commercially available Viral Transport Mediums (VTMs) to inactivate SARS-CoV-2. Independent testing methods for viral inactivation testing were applied, including a previously described World Health…

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A review of nasopharyngeal swab and saliva tests for SARS‐CoV‐2 infection: Disease timelines, relative sensitivities, and test optimization

November 11, 2021

Abstract Testing is an essential part of containment of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic. This review summarizes studies for SARS‐CoV‐2 infection and testing. Nasopharyngeal samples are best at sensitivity detection, especially in early stages of disease and in asymptomatic individuals. Current swab processing involves a 100‐ to 1000‐fold dilution of the…

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Sample collection and transport strategies to enhance yield, accessibility, and biosafety of COVID-19 RT-PCR testing

November 11, 2021

Abstract Introduction. Non-invasive sample collection and viral sterilizing buffers have independently enabled workflows for more widespread COVID-19 testing by reverse-transcriptase polymerase chain reaction (RT-PCR). Gap statement. The combined use of sterilizing buffers across non-invasive sample types to optimize sensitive, accessible, and biosafe sampling methods has not been directly and systematically compared. Aim. We aimed to…

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Beyond COVID-19—will self-sampling and testing become the norm?

November 11, 2021

In the fight against COVID-19, the general population in many countries has not been empowered to pursue diagnostic testing, but rather has been a subject to often frustrating and inadequate testing capacity. Diagnostics have been a cornerstone of the COVID-19 response globally, because strategies to contain and respond to the pandemic rely primarily on case…

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Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assays

November 4, 2021

Abstract BackgroundUpper respiratory samples used to test for SARS-CoV-2 virus may be infectious and presenta hazard during transport and testing. A buffer with the ability to inactivate SARS-CoV-2 atthe time of sample collection could simplify and expand testing for COVID-19 to non-conventionalsettings. MethodsWe evaluated a guanidium thiocyanate-based buffer, eNAT™ (Copan) as a possible transportand inactivation…

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Rapid and accurate eXDR screening: use Xpert Carba-R with FecalSwab

November 4, 2021

ABSTRACT The FecalSwab® displays high performances for stool culture, but it was not assessed for carbapenemase-producing Enterobacterales (CPE) screening. We assess the performances of the Xpert Carba-R v2® with the FecalSwab®. Using a collection of 12 CPE strains, the limit of detection was assessed at 158 CFU/swab [interquartile range 93–589]. In 2019, 1540 swabs were…

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Relative sensitivity of anterior nares and nasopharyngeal swabs for initial detection of SARS-CoV-2 in ambulatory patients: Rapid review and meta-analysis

July 22, 2021

Abstract Nasopharyngeal (NP) swabs are considered the “gold standard” for diagnosing SARS-CoV-2 infections, but anterior nares or mid-turbinate swabs (nasal swabs) are often used. We performed a meta-analysis comparing the sensitivity of nasal and nasopharyngeal swabs against a composite reference standard for the initial diagnosis of SARS-CoV-2 infection inambulatory patients. The study is registered on…

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Multicenter Evaluation of Processing and Analysis of CAP Proficiency Testing Samples by Laboratory Automation

February 17, 2021

To maintain their Clinical Laboratory Improvement Amendment (CLIA) accreditation, clinical laboratories are expected to enroll in proficiency testing (PT) to confirm that all parts of the diagnostic testing process perform as expected (1). In recent years, an increasing number of clinical microbiology laboratories have adopted laboratory automation for processing and incubation of specimens submitted for…

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Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV-2 Molecular Detection: A Systematic Review and Meta-analysis

February 16, 2021

This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. ABSTRACT Background Nasopharyngeal (NP) swabs are considered the highest-yield sample for diagnostic testing for respiratory viruses, including SARS-CoV-2. The need to increase capacity…

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Copan eNAT™ Transport System to Address Challenges in COVID-19 Diagnostics in Regions with Limited Testing Access

February 12, 2021

ABSTRACT Community-based healthcare clinics and hospital outreach services have the potential to expand coronavirus disease 2019 (COVID-19) diagnostics to rural areas. However, reduced specimen stability during extended transport, the absence of cold chain to centralized laboratories, and biosafety concerns surrounding specimen handling has limited this expansion. In the following study, we evaluated eNAT (Copan Italia,…

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Variability in instructions for performance of nasopharyngeal swabs across Canada in the era of COVID-19 – what type of swab is actually being performed?

February 11, 2021

Abstract Background The primary method of surveillance for the presence of SARS-CoV-2 is with nasopharyngeal swabs. Given the significant demand for nasopharyngeal swabs, a large number of previously untrained and unfamiliar staff are now performing this test. It was noted that there was significant heterogeneity in instructions for performing nasopharyngeal swabs in Canada, in contrast…

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The impact of viral transport media on PCR assay results for the detection of nucleic acid from SARS-CoV-2

February 2, 2021

Sir, For several decades a variety of medium solutions have been recommended to stabilise specimens for the detection of bacteria and viruses, particularly during diagnostic investigations. These have usually been based on balanced salt or saline solutions with a buffering capacity to maintain a ‘near-neutral’ pH. To enhance the stability of viruses a spectrum of…

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Detection of SARS-CoV-2 from Saliva as Compared to Nasopharyngeal Swabs in Outpatients

February 2, 2021

Abstract Widely available and easily accessible testing for COVID-19 is a cornerstone of pandemic containment strategies. Nasopharyngeal swabs (NPS) are the currently accepted standard for sample collection but are limited by their need for collection devices and sampling by trained healthcare professionals. The aim of this study was to compare the performance of saliva to…

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Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study

February 2, 2021

Abstract Background The PCV13 immunization demonstration program began in October 2017 in Indonesia. The aim of this study is to assess the dynamic changes of pneumococcal serotype before and after PCV13 administration, with two primary and one booster doses. Methods The prospective cohort study was conducted as a follow up study measuring the impact of…

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Earliest detection to date of SARS-CoV-2 in Florida: Identification together with influenza virus on the main entry door of a university building, February 2020

February 2, 2021

Abstract In February and March, 2020, environmental surface swab samples were collected from the handle of the main entry door of a major university building in Florida, as part of a pilot surveillance project screening for influenza. Samples were taken at the end of regular classroom hours, between the dates of February 1–5 and February…

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Some of the studies in this database are independent scientific studies performed by third parties, while some of the studies were partially or entirely funded by COPAN. In addition to peer reviewed research this library also contains posters, which were presented at various scientific meetings, and may not have been subject to peer review.

Some of the studies found here may contain information about off label product use. Studies, product claims and availability may vary from country to country, and they are subject to varying regulatory requirements. Always refer to product labeling, package inserts and safety data sheets for the appropriate use of the products.