Virus Isolation from the First Patient with SARS-CoV-2 in Korea
ABSTRACT
Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS-CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS-CoV-2 reported from Wuhan.
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Full Scientific Study
Date
February 17, 2020
Conference or Journal
J Korean Med Sci. 2020 Feb 24;35(7):e84
Author(s)
Wan Beom Park
Nak-Jung Kwon
Su-Jin Choi
Chang Kyung Kang
Pyoeng Gyun Choe
Jin Yong Kim
Jiyoung Yun
Gir-Won Lee
Moon-Woo Seong
Nam Joong Kim
Jeong-Sun Seo
Myoung-don Oh