COVID-19 Sample Collection and Transport Resources

Taking a swab for corona virus sample

CDC and FDA Guidelines

Due to the recent COVID-19 pandemic, we have received many inquiries about which types of swabs, media, and kits can be used for COVID-19 sample collection before testing. Below we have a short guide on which COPAN products meet the CDC and FDA Guidelines. All testing for COVID-19 should be conducted in consultation with a healthcare provider. COPAN Diagnostics, Inc. sells only through distribution partners.


    Contents


What Kind of Swabs are Suitable for COVID-19 Sample Collection?

As outlined in the CDC guidelines for the collection and handling of clinical specimens from patients suspected of being infected COVID-19, health care workers should only use synthetic fiber swabs with plastic shafts. [1]* According to the FDA, “nasopharyngeal (NP) specimens are generally considered to yield the most sensitive test results” and “sample collection with a flocked swab, when available, is preferred”[2] Both of the CDC and FDA recommendations are covered when using a COPAN NP FLOQSwabs®.


*Do not use calcium alginate swabs or swabs with wooden shafts when testing for COVID-19. These swabs can contain substances that inactivate some viruses and can inhibit PCR testing [1].

Click Here to learn more about COPAN’s flocked swabs


What Sampling Method is Appropriate for COVID-19 Detection? 

In the CDC Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Persons Under Investigation (PUIs) for COVID-19, the CDC recommends collecting and testing a NP swab. If both a nasopharyngeal and an oropharyngeal (OP) swab are taken, the specimens should be combined at the collection site into a single transport vial. [2]

Multiple specimens from the same patient may be taken with a single swab. If more than one swab is used for collecting specimens from two different locations in the same patient, both swabs may be placed in the same vial in order to conserve collection and assay supplies.


(Read section below “Are There Good Alternatives to Nasopharyngeal Flocked Swabs for COVID-19?” if stock is unavailable)


Are There Good Alternatives to Nasopharyngeal Flocked Swabs for COVID-19?

In this video, Norman Sharples, COPAN Diagnostics’ CEO, discusses the different sites and swab materials available for sample collection for COVID-19 based on the FDA Guidelines as of April 1, 2020. FDA believes that a nasopharyngeal specimen is a preferred choice for swab-based COVID-19 testing.

According to the FDA, if a nasopharyngeal specimen is not available, the following are acceptable [2]:

  • Oropharyngeal (OP) specimen collected by an HCP using a swab with a full-sized tip;

  • Mid-turbinate specimen collected by an HCP or by onsite self-collection using a specialized, flocked tapered swab; or

  • Anterior nares specimen collected by an HCP or by onsite self-collection using a flocked swab, round foam swab, or spun fiber swab. For anterior nares specimen collection, a swab with a full-sized tip (OP-type swab) is generally preferred over a swab with a mini-tip (NP-type swab).

The situation regarding the types of sample collection kits acceptable for COVID-19 testing remains fluid. Consult the current CDC and FDA guidance.


What Transport Media Should be Used for COVID-19?

The CDC guidelines direct healthcare workers to place swabs immediately into sterile tubes containing 2-3 ml of viral transport media [1], like COPAN UTM® Universal Transport Medium [1].

Click Here to learn more about COPAN’s UTM®

In the absence of viral transport medium or UTM®, liquid Amies media, a medium found in COPAN ESwab™, may be used. Other solutions may also be used for viral transport when UTM® is not available. Consult the current guidance for information on alternatives for transport media at the FDA Medical Devices Emergency Situations – FAQs on Diagnostic Testing for SARS-CoV-2.

Click Here to learn more about COPAN’s Eswab™


What Kinds of COVID-19 Sample Collection Kits are Available?

COPAN makes COVID-19 collection and transport kits that are compatible with the recommended configuration that pairs 3mL of UTM® universal viral transport medium with flocked swab(s).

Also, healthcare providers can quickly assemble in-house sample collection kits and place the items in a Ziploc/Minigrip bag for distribution using the different COPAN item numbers listed in the section below.


Distributor Links & Part Numbers

In the United States, COPAN does not sell sample collection products directly to clinical laboratories. Our products are available through our distribution partners. Here you will find information about recommended sample collection swabs and transport media as well as distributor part numbers.

Distributor Links

Distributor Part Numbers


Illustrated Sampling Guides for COVID-19

There are 3 recommended sample sites for both COPAN ESwab™ and UTM® Universal Transport Medium collection kits. Below are examples of guides that can be used to illustrate how to collect viral specimens from different sites. Always read the manufacturer’s package insert for specific instructions regarding specimen collection and transport for the type of test kit being used.


Additional COVID-19 Resources Published by ASM

The information and research around COVID-19 are rapidly evolving. Below, we have included several resources to help stay current on the most important developments.

ASM COVID-19 Research Registry

An expert-curated collection of the latest and most significant research findings and information about COVID-19. Topics include Basic Virology, Clinical Diagnostics, Treatment, Prevention & Epidemiology.

ASM COVID-19 Tracker and Q&A

A page including general information on COVID-19, infection tracker and Q&A with Robin Patel, M.D., President of ASM, Chair of the Division of Clinical Microbiology and Director of the Infectious Diseases Laboratory at Mayo Clinic, in Rochester, Minnesota


References

  1. Centers for Disease Control and Prevention. (2020, February 14). Coronavirus Disease 2019 (COVID-19): Guidelines for Clinical Specimens. Retrieved February 27, 2020, from https://www.cdc.gov/coronavirus/2019-nCoV/lab/guidelines-clinical-specimens.html
  2. Food and Drug Administration COVID19 FAQs website: https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/faqs-testing-sars-cov-2

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